More random alien, big creature, and Random Ray Usage(tm!) from Detective Comics #305, where the big mystery seems to be, "How many times can we recycle these plot devices?"
I suppose it's unique in that this story has aliens, big creatures, and Random Ray Usage(tm!)
Here's an out-of-context panel that I find funny if you have no idea what led up to it:
Even the back-up story in that issue had Random Ray Usage(tm!):
The future.... where no man shall wear long pants.
See you tomorrow!