Super-speed is probably the third most-used power, right behind flight and super-strength. I have nothing to back this up, really, but I'll bet I'm right.
The problem with being a super-fast guy is that everyone wants to slow you down. Like thus:
Or even thusly, going as far back as WWII:
There are all kinds of logistical problems with being a speedster. The most obvious one is how friction keeps from burning your clothes clean off. I suppose Marvel can blame "unstable molecules," which they also use to explain how other character's clothes stretch, shrink, expand, turn invisible, or don't burn even though the wearer is consumed by self-generated flames.
Only problem is: (1) Reed Richards supposedly invented the "unstable molecules," which means that any Golden Age hero should have been running around naked half the time (which would have been perfectly fine in the case of the Phantom Lady, but you see where I'm coming from) and (2) it really doesn't help non-Marvel characters. Sure, Superman has an indestructible costume from Krypton and I suppose your magic types have got things well in hand, but what about the Golden Age Flash, Johnny Quick, the original Human Torch or Plastic Man? Who is supplying these people with these miracle fabrics?
Another thing about being a speedster that bugs me:
I am no physicist, but I challenge that you are impervious to harm just because you run into something quick enough. It seems to me like the quicker you run into something, the more likely you are to break some bones. This whole "pinball" stunt gets used a lot, and I'm just not sure that moving really fast has anything to do with how much of an impact you can withstand. I mean, if I run as fast as I can into a wall, someone better call the paramedics.
One thing I never understood about Goliath:
This is the "Hawkeye decides to toss his arrows for no reason and starts using Hank Pym's growth formula" Goliath, not the one you normally think of. And, I'm telling ya, the guy stayed huge as much as possible, even when inconvenient or unnecessary, like you see here. It seems dang inconsiderate to make people go out and find tremendously over-sized teacups, not to mention requiring them to serve you from your crotch region. With or without arrows, Hawkeye was something of a douche.
Enough over-analyzing! Cue the Law-Enforcement Produced Anti-Drug PSA!: